Pharmacokinetic-pharmacodynamic profile of systemic nitric oxide-synthase inhibition with L-NMMA in humans

AIMS: It has been demonstrated that inhibition of endothelium derived nitric oxide with N(G)-monomethyl-l-arginine (l-NMMA) results in a different cardiac and peripheral vascular response. The purpose of this study was to investigate the pharmacokinetic-pharmacodynamic profile of l-NMMA and pharmaco...

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Detalhes bibliográficos
Main Authors: Mayer, Bernhard X, Mensik, Christa, Krishnaswami, Sriram, Derendorf, Hartmut, Eichler, Hans-Georg, Schmetterer, Leopold, Wolzt, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1999
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014188/
https://ncbi.nlm.nih.gov/pubmed/10336578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00930.x
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