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Tolterodine does not affect the human in vivo metabolism of the probe drugs caffeine, debrisoquine and omeprazole

AIM: To investigate the in vivo effect of treatment with tolterodine on debrisoquine 4-hydroxylation (an index of CYP2D6 activity), omeprazole 5-hydroxylation (CYP2C19), omeprazole sulphoxidation (CYP3A4) and caffeine N(3)-demethylation (CYP1A2). METHODS: Twelve healthy male volunteers (eight extens...

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Detalhes bibliográficos
Main Authors: Brynne, N, Böttiger, Y, Hallén, B, Bertilsson, L
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014166/
https://ncbi.nlm.nih.gov/pubmed/10190648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1999.00865.x
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