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The plasma membrane Na(+)/Ca(2+) exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca(2+) uniporter

BACKGROUND AND PURPOSE: The thiourea derivative KB-R7943, originally developed as inhibitor of the plasma membrane Na(+)/Ca(2+) exchanger, has been shown to protect against myocardial ischemia-reperfusion injury. We have studied here its effects on mitochondrial Ca(2+) fluxes. EXPERIMENTAL APPROACH....

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書誌詳細
主要な著者: Santo-Domingo, J, Vay, L, Hernández-SanMiguel, E, Lobatón, C D, Moreno, A, Montero, M, Alvarez, J
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014000/
https://ncbi.nlm.nih.gov/pubmed/17471180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707260
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