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The plasma membrane Na(+)/Ca(2+) exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca(2+) uniporter
BACKGROUND AND PURPOSE: The thiourea derivative KB-R7943, originally developed as inhibitor of the plasma membrane Na(+)/Ca(2+) exchanger, has been shown to protect against myocardial ischemia-reperfusion injury. We have studied here its effects on mitochondrial Ca(2+) fluxes. EXPERIMENTAL APPROACH....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2014000/ https://ncbi.nlm.nih.gov/pubmed/17471180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707260 |
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