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Role of neutrophil elastase in LTB(4)-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice

BACKGROUND AND PURPOSE: The serine protease neutrophil elastase (NE) appears to regulate inflammatory responses at multiple levels but its role in leukocyte transmigration in vivo remains unclear. The present study aimed to address this issue by using both an NE inhibitor (ONO-5046) and NE deficient...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Young, R E, Voisin, M-B, Wang, S, Dangerfield, J, Nourshargh, S
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013993/
https://ncbi.nlm.nih.gov/pubmed/17471175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707267
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