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Agonist-dependent consequences of proline to alanine substitution in the transmembrane helices of the calcitonin receptor
BACKGROUND AND PURPOSE: Transmembrane proline (P) residues in family A G protein-coupled receptors (GPCRs) form functionally important kinks in their helices. These residues are little studied in family B GPCRs but experiments with the VPAC1 receptor and calcitonin receptor-like receptor (CL) show p...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2013989/ https://ncbi.nlm.nih.gov/pubmed/17486143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707246 |
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