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Cytokine upregulation of proteinase-activated-receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase β in human endothelial cells

BACKGROUND AND PURPOSE: Up-regulation of proteinase-activated receptor-2 (PAR2) is a factor in a number of disease states and we have therefore examined the signalling pathways involved in the expression of the receptor. EXPERIMENTAL APPROACH: We investigated the effects of tumour necrosis factor-α...

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Detalhes bibliográficos
Main Authors: Ritchie, E, Saka, M, MacKenzie, C, Drummond, R, Wheeler-Jones, C, Kanke, T, Plevin, R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013917/
https://ncbi.nlm.nih.gov/pubmed/17339845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707150
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