Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis

BACKGROUND AND PURPOSE: Mesalamine is the first-line therapy for colitis, but it lacks potency and is only effective for mild-to-moderate forms of this disease. Hydrogen sulphide has been shown to be a potent, endogenous anti-inflammatory substance, modulating leukocyte-endothelial adhesion and leuk...

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Главные авторы: Fiorucci, S, Orlandi, S, Mencarelli, A, Caliendo, G, Santagada, V, Distrutti, E, Santucci, L, Cirino, G, Wallace, J L
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2007
Предметы:
Research Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013915/
https://ncbi.nlm.nih.gov/pubmed/17339831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707193
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