5-HT(4) receptor agonists increase sAPPα levels in the cortex and hippocampus of male C57BL/6j mice

BACKGROUND AND PURPOSE: A strategy to treat Alzheimer's disease (AD) is to increase the soluble form of amyloid precursor protein (sAPPα), a promnesic protein, in the brain. Because strong evidence supports beneficial effects of 5-hydroxytryptamine 5-HT(4) receptor agonists in memory and learni...

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Autores principales: Cachard-Chastel, M, Lezoualc'h, F, Dewachter, I, Deloménie, C, Croes, S, Devijver, H, Langlois, M, Van Leuven, F, Sicsic, S, Gardier, A M
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2007
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013878/
https://ncbi.nlm.nih.gov/pubmed/17325649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707178
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