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Point mutations at the purine nucleoside phosphorylase locus impair thymocyte differentiation in the mouse

Three point mutations on the Np(b) allele of the purine nucleoside phosphorylase locus in the mouse have been recovered by male germ cell mutagenesis. The mutants were backcrossed, 12–14 generations, and are designated in increasing order of severity of enzyme deficiency and phenotype: B6-NPE, Met-8...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Snyder, Floyd F., Jenuth, Jack P., Mably, Ellen R., Mangat, Rupinder K.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20121/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9122228/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.6.2522
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