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Enhancement of the action of alkylating agents by single high, or chronic low doses of misonidazole.

Misonidazole (MISO) given as a large single dose enhanced the action of cyclophosphamide (Cy) and melphalan (L-PAM) in two mouse tumours. Below a dose of about 500 mg kg-1 it had no chemosensitizing effect. When MISO was given as a series of small doses by repeat injection over an 8 h period, in ord...

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Dettagli Bibliografici
Autori principali: McNally, N. J., Hinchliffe, M., de Ronde, J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1983
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2011437/
https://ncbi.nlm.nih.gov/pubmed/6882665
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