Enhancement of the DNA cross-linking activity of melphalan by misonidazole in vivo.

The technique of alkaline elution has been adapted for the study of drug-induced DNA cross-link formation in vivo. Pretreatment with misonidazole (MISO) enhances the number of cross-links formed in a fibrosarcoma and in the spleen and gut of mice for periods up to 48 h following a single injection o...

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Bibliographic Details
Main Authors: Murray, D., Meyn, R. E.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1983
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2011274/
https://ncbi.nlm.nih.gov/pubmed/6824567
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