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Effects of local hyperthermia on the pharmacokinetics of misonidazole in the anaesthetized mouse.

The effects of sodium pentobarbitone anaesthesia, the presence of a tumour, and local hyperthermia to a tumour-bearing leg, on the pharmacokinetics of MISO in the mouse are reported. Analysis of MISO and its metabolite Ro 05-9963 was by high-performance liquid chromatography. The plasma kinetics of...

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Main Authors: Honess, D. J., Workman, P., Morgan, J. E., Bleehen, N. M.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 1980
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2010260/
https://ncbi.nlm.nih.gov/pubmed/7387851
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