The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids

BACKGROUND: The 8-amino and 9-hydroxy substituents of antimalarial cinchona alkaloids have the erythro orientation while their inactive 9-epimers are threo. From the X-ray structures a 90° difference in torsion angle between the N1-H1 and C9-O12 bonds in the two series is believed to be important. I...

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Detaylı Bibliyografya
Asıl Yazarlar: Warhurst, David C, Craig, John C, Adagu, Ipemida S, Meyer, David J, Lee, Sylvia Y
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2003
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC201021/
https://ncbi.nlm.nih.gov/pubmed/14505493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-2-26
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