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The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids
BACKGROUND: The 8-amino and 9-hydroxy substituents of antimalarial cinchona alkaloids have the erythro orientation while their inactive 9-epimers are threo. From the X-ray structures a 90° difference in torsion angle between the N1-H1 and C9-O12 bonds in the two series is believed to be important. I...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2003
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC201021/ https://ncbi.nlm.nih.gov/pubmed/14505493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-2-26 |
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