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Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes

PPARγ is a ligand-activated transcription factor and functions as a heterodimer with a retinoid X receptor (RXR). Supraphysiological activation of PPARγ by thiazolidinediones can reduce insulin resistance and hyperglycemia in type 2 diabetes, but these drugs can also cause weight gain. Quite unexpec...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Yamauchi, Toshimasa, Waki, Hironori, Kamon, Junji, Murakami, Koji, Motojima, Kiyoto, Komeda, Kajuro, Miki, Hiroshi, Kubota, Naoto, Terauchi, Yasuo, Tsuchida, Atsuko, Tsuboyama-Kasaoka, Nobuyo, Yamauchi, Naoko, Ide, Tomohiro, Hori, Wataru, Kato, Shigeaki, Fukayama, Masashi, Akanuma, Yasuo, Ezaki, Osamu, Itai, Akiko, Nagai, Ryozo, Kimura, Satoshi, Tobe, Kazuyuki, Kagechika, Hiroyuki, Shudo, Koichi, Kadowaki, Takashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2001
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Article
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC200951/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11581301/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI12864
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