Response of rat lung to 3,4-benzpyrene administered by intratracheal instillation in infusine with or without carbon black.

In a controlled experiment groups of SPF Wistar rats were give 18 once-fortnightly doses of 0-5, 1-0 or 2-0 mg 3,4-benzpyrene (BP) suspended in infusine (I) or in carbon black (CB) + I by intratracheal instillation. Of rats examined post mortem, 1/16 given I+CB only, 0/16 given I only, 15/51 given B...

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Main Authors: Davis, B. R., Whitehead, J. K., Gill, M. E., Lee, P. N., Butterworth, A. D., Roe, F. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1975
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2009456/
https://ncbi.nlm.nih.gov/pubmed/1156525
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