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Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy

Primary T cell proliferative responses to TCR ligation plus CD28 costimulation are surprisingly heterogeneous. Many cells that enter G1 fail to progress further through the cell cycle, and some of these cells subsequently fail to divide upon restimulation, even in the presence of IL-2. Such IL-2–ref...

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Detalhes bibliográficos
Main Authors: Wells, Andrew D., Walsh, Matthew C., Bluestone, Jeffrey A., Turka, Laurence A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC200935/
https://ncbi.nlm.nih.gov/pubmed/11560959
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