Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

In mice, the mdr1a and mdr1b genes encode drug-transporting proteins that can cause multidrug resistance in tumor cells by lowering intracellular drug levels. These P-glycoproteins are also found in various normal tissues such as the intestine. Because mdr1b P-glycoprotein is not detectable in the i...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Sparreboom, Alex, van Asperen, Judith, Mayer, Ulrich, Schinkel, Alfred H., Smit, Johan W., Meijer, Dirk K. F., Borst, Piet, Nooijen, Willem J., Beijnen, Jos H., van Tellingen, Olaf
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20037/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9050899/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.5.2031
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