Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection

Cytotoxic T lymphocytes (CTLs) are thought to play a crucial role in the termination of the acute primary HIV-1 syndrome, but clear evidence for this presumption has been lacking. Here we demonstrate positive selection of HIV-1 proviral sequences encoding variants within a CTL epitope in Nef, a gene...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Price, David A., Goulder, Philip J. R., Klenerman, Paul, Sewell, Andrew K., Easterbrook, Philippa J., Troop, Maxine, Bangham, Charles R. M., Phillips, Rodney E.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1997
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20013/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9050875/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.5.1890
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