Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection

Cytotoxic T lymphocytes (CTLs) are thought to play a crucial role in the termination of the acute primary HIV-1 syndrome, but clear evidence for this presumption has been lacking. Here we demonstrate positive selection of HIV-1 proviral sequences encoding variants within a CTL epitope in Nef, a gene...

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Detalhes bibliográficos
Main Authors: Price, David A., Goulder, Philip J. R., Klenerman, Paul, Sewell, Andrew K., Easterbrook, Philippa J., Troop, Maxine, Bangham, Charles R. M., Phillips, Rodney E.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC20013/
https://ncbi.nlm.nih.gov/pubmed/9050875
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