The selective κ-opioid receptor agonist U50,488 reduces L-dopa-induced dyskinesias but worsens parkinsonism in MPTP-treated primates

Several lines of evidence demonstrate that the striatal enkephalinergic system may be involved in the development of LIDs. Preproenkephalin-B (PPE-B) transcript levels are elevated with LIDs and there are also declines in κ- and other opioid receptors in different regions of the basal ganglia. If re...

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Main Authors: Cox, Heather, Togasaki, Daniel M., Chen, Li, Langston, J. William, Di Monte, Donato A., Quik, Maryka
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2001245/
https://ncbi.nlm.nih.gov/pubmed/17335811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2007.01.024
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