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Development of selective inhibitors for anti-apoptotic Bcl-2 proteins from BHI-1
A series of inhibitors for anti-apoptotic Bcl-2 proteins based on BHI-1 were synthesized and their binding interactions with Bcl-2, Bcl-X(L), and Bcl-w were evaluated. It was found that modification of BHI-1 resulted in varied binding profiles among Bcl-2, Bcl-X(L), and Bcl-w and a set of inhibitors...
Shranjeno v:
| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2001163/ https://ncbi.nlm.nih.gov/pubmed/17227711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2006.12.020 |
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