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Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor γ(c) chain for Janus kinase activation leading to T cell proliferation
The interleukin 2 receptor (IL-2R) generates proliferative signals in T lymphocytes by ligand-induced heterodimerization of two chains, IL-2Rβ and γ(c), which associate with the tyrosine kinases Jak1 and Jak3, respectively. Genetic and molecular studies have demonstrated that Jak3 is essential for m...
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| Asıl Yazarlar: | , , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The National Academy of Sciences of the USA
1997
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC20011/ https://ncbi.nlm.nih.gov/pubmed/9050873 |
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