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APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase
During the G1/S transition, p21 proteolysis is mediated by Skp2; however, p21 re-accumulates in G2 and is degraded again in prometaphase. How p21 degradation is controlled in mitosis remains unexplored. We found that Cdc20 (an activator of the ubiquitin ligase APC/C) binds p21 in cultured cells and...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2000825/ https://ncbi.nlm.nih.gov/pubmed/17679094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.06.013 |
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