Cytoplasmic localization of p27 (CDKN1B / KIP1) in colorectal cancer: inverse correlations with nuclear p27 loss, microsatellite instability and CpG island methylator phenotype (CIMP)

Cytoplasmic mislocalization of p27 (cyclin-dependent kinase inhibitor-1B, CDKN1B/KIP1) is caused by activated AKT1, and has been associated with poor prognosis in various cancers. CpG island methylator phenotype (CIMP) in colorectal cancer is characterized by extensive promoter methylation, and is a...

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Hlavní autoři: Ogino, Shuji, Kawasaki, Takako, Ogawa, Akiyo, Kirkner, Gregory J., Loda, Massimo, Fuchs, Charles S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000822/
https://ncbi.nlm.nih.gov/pubmed/17239930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humpath.2006.09.014
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