A mechanism-based binding model for the population pharmacokinetics and pharmacodynamics of omalizumab

AIM: Omalizumab, a humanized IgG monoclonal antibody that binds to human immunoglobulin E (IgE), interrupts the allergic cascade in asthmatic patients. The aim was to compare simultaneously drug exposure and IgE biomarker responses in Japanese and White patient populations. METHODS: An instantaneous...

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Autores principales: Hayashi, Naoto, Tsukamoto, Yuko, Sallas, William M, Lowe, Philip J
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2007
Materias:
Pharmacokinetics & Pharmacodynamics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000760/
https://ncbi.nlm.nih.gov/pubmed/17096680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02803.x
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