Pharmacokinetics and safety assessments of high-dose and 4-week treatment with S-3304, a novel matrix metalloproteinase inhibitor, in healthy volunteers

AIMS: To investigate the tolerability, safety and pharmacokinetics of S-3304 in healthy volunteers treated with high doses of S-3304 for 28 days. METHODS: Thirty-two healthy volunteers were recruited. Four male and four female subjects were allocated to one of four doses (800 mg, 1600 mg, 2400 mg an...

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Main Authors: Mant, Timothy G K, Bradford, Daniel, Amin, Dipti M, Pisupati, Jaya, Kambayashi, Yoshikazu, Yano, Yoshitaka, Tanaka, Kazushige, Yamada-Sawada, Takuko
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2007
Fag:
Pharmacokinetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000759/
https://ncbi.nlm.nih.gov/pubmed/17076695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02794.x
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