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Effect of ABCB1 (MDR1) haplotypes derived from G2677T/C3435T on the pharmacokinetics of amlodipine in healthy subjects

AIM: We aimed to investigate the effect of the ABCB1 gene on the pharmacokinetics of amlodipine. METHODS: Based on polymorphisms of the ABCB1 gene at positions 2677 and 3435, 26 healthy male participants were divided into three groups: subjects with 2677GG/3435CC (n = 9), 2677GT/3435CT (n = 9) and 2...

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Detalhes bibliográficos
Main Authors: Kim, Kyoung-Ah, Park, Pil-Whan, Park, Ji-Young
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000718/
https://ncbi.nlm.nih.gov/pubmed/16869811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02733.x
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