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Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin

Genes encoding type VI secretion systems (T6SS) are widely distributed in pathogenic Gram-negative bacterial species. In Vibrio cholerae, T6SS have been found to secrete three related proteins extracellularly, VgrG-1, VgrG-2, and VgrG-3. VgrG-1 can covalently cross-link actin in vitro, and this acti...

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Detalhes bibliográficos
Main Authors: Pukatzki, Stefan, Ma, Amy T., Revel, Andrew T., Sturtevant, Derek, Mekalanos, John J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000545/
https://ncbi.nlm.nih.gov/pubmed/17873062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706532104
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