Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC

The biosynthesis of rebeccamycin, an antitumor compound, involves the remarkable eight-electron oxidation of chlorinated chromopyrrolic acid. Although one rebeccamycin biosynthetic enzyme is capable of generating low levels of the eight-electron oxidation product on its own, a second protein, RebC,...

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Bibliographische Detailangaben
Hauptverfasser: Ryan, Katherine S., Howard-Jones, Annaleise R., Hamill, Michael J., Elliott, Sean J., Walsh, Christopher T., Drennan, Catherine L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000502/
https://ncbi.nlm.nih.gov/pubmed/17873060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707190104
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