A mouse model for nonsense mutation bypass therapy shows a dramatic multiday response to geneticin

Aminoglycosides can bypass nonsense mutations and are the prototypic agents for translational bypass therapy (TBT). Initial results demonstrate the need for more potent drugs and an in vivo model system for quantitative assessment of TBT. Herein, we present an in vivo system for evaluating the effic...

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Hlavní autoři: Yang, Chunmei, Feng, Jinong, Song, Wenjia, Wang, Jicheng, Tsai, Becky, Zhang, Yunwu, Scaringe, William A., Hill, Kathleen A., Margaritis, Paris, High, Katherine A., Sommer, Steve S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000501/
https://ncbi.nlm.nih.gov/pubmed/17881586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610878104
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