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A model for the role of integrins in flow induced mechanotransduction in osteocytes

A fundamental paradox in bone mechanobiology is that tissue-level strains caused by human locomotion are too small to initiate intracellular signaling in osteocytes. A cellular-level strain-amplification model previously has been proposed to explain this paradox. However, the molecular mechanism for...

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Detalhes bibliográficos
Main Authors: Wang, Yilin, McNamara, Laoise M., Schaffler, Mitchell B., Weinbaum, Sheldon
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000405/
https://ncbi.nlm.nih.gov/pubmed/17895377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707246104
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