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Missense mutations in pancreatic secretory trypsin inhibitor (SPINK1) cause intracellular retention and degradation
BACKGROUND/AIMS: Mutations of the SPINK1 gene encoding pancreatic secretory trypsin inhibitor have been identified in association with chronic pancreatitis. The vast majority of patients carry the N34S variant, whereas other genetic variants are relatively rare and their disease association is uncer...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMJ Group
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2000263/ https://ncbi.nlm.nih.gov/pubmed/17525091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2006.115725 |
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