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Multiple mechanisms of N-phosphonacetyl-l-aspartate resistance in human cell lines: Carbamyl-P synthetase/aspartate transcarbamylase/dihydro-orotase gene amplification is frequent only when chromosome 2 is rearranged

Rodent cells resistant to N-phosphonacetyl-l-aspartate (PALA) invariably contain amplified carbamyl-P synthetase/aspartate transcarbamylase/dihydro-orotase (CAD) genes, usually in widely spaced tandem arrays present as extensions of the same chromosome arm that carries a single copy of CAD in normal...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Smith, Kathleen A., Chernova, Olga B., Groves, Richard P., Stark, Mary B., Martínez, José L., Davidson, Jeffrey N., Trent, Jeffrey M., Patterson, Thomas E., Agarwal, Archana, Duncan, Pamela, Agarwal, Munna L., Stark, George R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20000/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9050862/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.5.1816
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