Multiple mechanisms of N-phosphonacetyl-l-aspartate resistance in human cell lines: Carbamyl-P synthetase/aspartate transcarbamylase/dihydro-orotase gene amplification is frequent only when chromosome 2 is rearranged

Rodent cells resistant to N-phosphonacetyl-l-aspartate (PALA) invariably contain amplified carbamyl-P synthetase/aspartate transcarbamylase/dihydro-orotase (CAD) genes, usually in widely spaced tandem arrays present as extensions of the same chromosome arm that carries a single copy of CAD in normal...

Descripción completa

Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Smith, Kathleen A., Chernova, Olga B., Groves, Richard P., Stark, Mary B., Martínez, José L., Davidson, Jeffrey N., Trent, Jeffrey M., Patterson, Thomas E., Agarwal, Archana, Duncan, Pamela, Agarwal, Munna L., Stark, George R.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1997
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20000/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9050862/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.5.1816
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!