Multiple mechanisms of N-phosphonacetyl-l-aspartate resistance in human cell lines: Carbamyl-P synthetase/aspartate transcarbamylase/dihydro-orotase gene amplification is frequent only when chromosome 2 is rearranged

Rodent cells resistant to N-phosphonacetyl-l-aspartate (PALA) invariably contain amplified carbamyl-P synthetase/aspartate transcarbamylase/dihydro-orotase (CAD) genes, usually in widely spaced tandem arrays present as extensions of the same chromosome arm that carries a single copy of CAD in normal...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Smith, Kathleen A., Chernova, Olga B., Groves, Richard P., Stark, Mary B., Martínez, José L., Davidson, Jeffrey N., Trent, Jeffrey M., Patterson, Thomas E., Agarwal, Archana, Duncan, Pamela, Agarwal, Munna L., Stark, George R.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The National Academy of Sciences of the USA 1997
Θέματα:
Biological Sciences
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC20000/
https://ncbi.nlm.nih.gov/pubmed/9050862
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