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Comparative genomics reveals functional transcriptional control sequences in the Prop1 gene
Mutations in PROP1 are a common genetic cause of multiple pituitary hormone deficiency (MPHD). We used a comparative genomics approach to predict the transcriptional regulatory domains of Prop1 and tested them in cell culture and mice. A BAC transgene containing Prop1 completely rescues the Prop1 mu...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Springer New York
2007
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1998882/ https://ncbi.nlm.nih.gov/pubmed/17557180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00335-007-9008-6 |
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