Integrin α(4)β(1) Regulates Migration across Basement Membranes by Lung Fibroblasts: A Role for Phosphatase and Tensin Homologue Deleted on Chromosome 10

Idiopathic pulmonary fibrosis is a disease that is characterized by fibroblast accumulation and activation in the distal airspaces of the lung. We hypothesized that fibrotic lung fibroblasts migrate/invade across basement membranes by integrin-mediated mechanisms as a means of entering alveoli. We d...

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Autori principali: White, Eric S., Thannickal, Victor J., Carskadon, Shannon L., Dickie, Emily G., Livant, Donna L., Markwart, Sonja, Toews, Galen B., Arenberg, Douglas A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2003
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1997294/
https://ncbi.nlm.nih.gov/pubmed/12791582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200301-041OC
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