Classical sickle beta-globin haplotypes exhibit a high degree of long-range haplotype similarity in African and Afro-Caribbean populations

BACKGROUND: The sickle (β(s)) mutation in the beta-globin gene (HBB) occurs on five "classical" β(s )haplotype backgrounds in ethnic groups of African ancestry. Strong selection in favour of the β(s )allele – a consequence of protection from severe malarial infection afforded by heterozygo...

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Autores principales: Hanchard, Neil, Elzein, Abier, Trafford, Clare, Rockett, Kirk, Pinder, Margaret, Jallow, Muminatou, Harding, Rosalind, Kwiatkowski, Dominic, McKenzie, Colin
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1997132/
https://ncbi.nlm.nih.gov/pubmed/17688704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2156-8-52
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