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Neutrophil-epithelial crosstalk at the intestinal lumenal surface mediated by reciprocal secretion of adenosine and IL-6

Adenosine is formed in the intestinal lumen during active inflammation from neutrophil-derived 5′ AMP. Using intestinal epithelial cell line T84, we studied the effect of adenosine on the secretion of IL-6, a proinflammatory cytokine involved in neutrophil degranulation and lymphocyte differentiatio...

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Udgivet i:J Clin Invest
Principais autores: Sitaraman, Shanthi V., Merlin, Didier, Wang, Lixin, Wong, Michelle, Gewirtz, Andrew T., Si-Tahar, Mustapha, Madara, James L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC199578/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11285305/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI11783
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