The Evolution of Catalytic Efficiency and Substrate Promiscuity in Human Theta Class 1-1 Glutathione Transferase

Theta class glutathione transferases (GST) from various species exhibit markedly different catalytic activities in conjugating the tripeptide glutathione (GSH) to a variety of electrophilic substrates. For example, the human theta 1-1 enzyme (hGSTT1-1) is 440-fold less efficient than the rat theta 2...

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Bibliographic Details
Main Authors: Griswold, Karl E., Aiyappan, Nandini S., Iverson, Brent L., Georgiou, George
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1995603/
https://ncbi.nlm.nih.gov/pubmed/17011574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.09.01
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