PPARα deficiency reduces insulin resistance and atherosclerosis in apoE-null mice

PPARα is a ligand-dependent transcription factor expressed at high levels in the liver. Its activation by the drug gemfibrozil reduces clinical events in humans with established atherosclerosis, but the underlying mechanisms are incompletely defined. To clarify the role of PPARα in vascular disease,...

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Hauptverfasser: Tordjman, Karen, Bernal-Mizrachi, Carlos, Zemany, Laura, Weng, Sherry, Feng, Chu, Zhang, Fengjuan, Leone, Teresa C., Coleman, Trey, Kelly, Daniel P., Semenkovich, Clay F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2001
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC199556/
https://ncbi.nlm.nih.gov/pubmed/11306606
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