Alcohol-induced S-adenosylhomocysteine Accumulation in the Liver Sensitizes to TNF Hepatotoxicity: Possible Involvement of Mitochondrial S-adenosylmethionine Transport

Hepatocytes are resistant to tumor necrosis factor-α- (TNF) induced killing/apoptosis under normal circumstances, but primary hepatocytes from rats chronically fed alcohol have increased TNF cytotoxicity. Therefore, there must be mechanism(s) by which alcohol exposure “sensitizes” to TNF hepatotoxic...

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Autori principali: Song, Zhenyuan, Zhou, Zhanxiang, Song, Ming, Uriarte, Silvia, Chen, Theresa, Deaciuc, Ion, McClain, Craig J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1995460/
https://ncbi.nlm.nih.gov/pubmed/17574213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2007.05.005
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