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Down syndrome candidate region 1-like 1 (DSCR1-L1) mimics the inhibitory effects of DSCR1 on calcineurin signaling in endothelial cells and inhibits angiogenesis
In endothelial cells, binding of vascular endothelial growth factor (VEGF) to VEGF receptor 2 (VEGFR-2) leads to the activation of the serine/threonine phosphatase calcineurin, dephosphorylation of the NF-AT transcription factors, translocation of NF-AT to the nucleus, and expression of angiogenesis...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1995402/ https://ncbi.nlm.nih.gov/pubmed/17610901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2006.10.011 |
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