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Protein synthesis inhibition as a potential strategy for metabolic down-regulation

OBJECTIVE: This pilot study tested the potential of puromycin (PUR) to inhibit protein synthesis and reduce oxygen utilization in a non-hibernating, whole animal preparation. METHODS: After anesthesia and instrumentation, male rats received a single dose of PUR or 0.9% saline (control), followed 60...

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Detalhes bibliográficos
Main Authors: Evans, Melissa C., Diegelmann, Robert F., Barbee, R. Wayne, Tiba, M. Hakam, Edwards, Eric, Sreedhar, Sue, Ward, Kevin R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1994718/
https://ncbi.nlm.nih.gov/pubmed/17250947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.resuscitation.2006.08.029
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