Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion

The flavivirus West Nile virus (WNV) is an emerging pathogen that causes life-threatening encephalitis in susceptible individuals. We investigated the role of the proinflammatory cytokine macrophage migration inhibitory factor (MIF), which is an upstream mediator of innate immunity, in WNV immunopat...

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Autors principals: Arjona, Alvaro, Foellmer, Harald G., Town, Terrence, Leng, Lin, McDonald, Courtney, Wang, Tian, Wong, Susan J., Montgomery, Ruth R., Fikrig, Erol, Bucala, Richard
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2007
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1994625/
https://ncbi.nlm.nih.gov/pubmed/17909632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32218
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