Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice

PTEN is a tumor suppressor gene mutated in many human cancers. We generated a bronchioalveolar epithelium–specific null mutation of Pten in mice [SP-C-rtTA/(tetO)(7)-Cre/Pten(flox/flox) (SOPten(flox/flox)) mice] that was under the control of doxycycline. Ninety percent of SOPten(flox/flox) mice that...

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Autori principali: Yanagi, Shigehisa, Kishimoto, Hiroyuki, Kawahara, Kohichi, Sasaki, Takehiko, Sasaki, Masato, Nishio, Miki, Yajima, Nobuyuki, Hamada, Koichi, Horie, Yasuo, Kubo, Hiroshi, Whitsett, Jeffrey A., Mak, Tak Wah, Nakano, Toru, Nakazato, Masamitsu, Suzuki, Akira
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1994617/
https://ncbi.nlm.nih.gov/pubmed/17909629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31854
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