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Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic β-cells

Long-chain saturated and monounsaturated fatty acids differ in their propensity to induce β-cell death in vitro with palmitate (C16:0) being cytotoxic, whereas palmitoleate (C16:1n-7) is cytoprotective. We now show that this cytoprotective capacity extends to a poorly metabolised C16:1n-7 derivative...

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Auteurs principaux: Diakogiannaki, Eleftheria, Dhayal, Shalinee, Childs, Caroline E, Calder, Philip C, Welters, Hannah J, Morgan, Noel G
Format: Artigo
Langue:Inglês
Publié: Society for Endocrinology 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1994570/
https://ncbi.nlm.nih.gov/pubmed/17641278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/JOE-07-0082
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