Cyclooxygenase-2 Deficiency Exacerbates Bleomycin-Induced Lung Dysfunction but Not Fibrosis

Cyclooxygenase (COX)-derived eicosanoids have been implicated in the pathogenesis of pulmonary fibrosis. Uncertainty regarding the influence of COX-2 on experimental pulmonary fibrosis prompted us to clarify the fibrotic and functional effects of intratracheal bleomycin administration in mice geneti...

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Detalhes bibliográficos
Main Authors: Card, Jeffrey W., Voltz, James W., Carey, Michelle A., Bradbury, J. Alyce, DeGraff, Laura M., Lih, Fred B., Bonner, James C., Morgan, Daniel L., Flake, Gordon P., Zeldin, Darryl C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1994226/
https://ncbi.nlm.nih.gov/pubmed/17496151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2007-0057OC
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