Lipopolysaccharide (LPS) directly suppresses growth hormone receptor (GHR) expression through MyD88-dependent and -independent Toll-like receptor-4/MD2 complex signaling pathways

INTRODUCTION: Sepsis is associated with growth hormone (GH) insensitivity and in the intact animal the major surface component of the bacterial cell wall, lipopolysaccharide (LPS), inhibits GH receptor (GHR) gene expression. The prevailing explanation for LPS-induced effects on the GHR promoter is t...

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Main Authors: Dejkhamron, Prapai, Thimmarayappa, Jamuna, Kotlyarevska, Kateryna, Sun, Jinhong, Lu, Chunxia, Bonkowski, Erin L, Denson, Lee A, Menon, Ram K
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1994148/
https://ncbi.nlm.nih.gov/pubmed/17601656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2007.05.013
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